A Clinical Guide to Stem Cell and Bone Marrow Transplantation


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Hemolysis from ABO Incompatibility. Daimon P. Simmons , William J. Andreas Holbro , Martin L. Engraftment syndrome after allogeneic hematopoietic cell transplantation predicts poor outcomes.

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Kucher , D. Donor-type fresh frozen plasma is effective in preventing hemolytic reaction in major ABO incompatible allogeneic stem cell transplant. Michniacki , Christen L.

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Ebens , Sung Won Choi. Transfusion support for matched sibling allogeneic hematopoietic stem cell transplantation : factors that predict intensity and time to transfusion independence. Linda M. References Publications referenced by this paper. Immune hemolysis following ABO-mismatched stem cell or solid organ transplantation. Mark H Yazer , Darrell J.

ABO incompatibility as an adverse risk factor for survival after allogeneic bone marrow transplantation. Hallowell Churchill , Joseph H Antin. How do I approach ABO-incompatible hematopoietic progenitor cell transplantation? Scientists have learned to make certain specialized cell types through a multi-step processes using pluripotent stem cells, that is embryonic stem cells or induced pluripotent stem iPS cells.

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Clinical guide to ABO-incompatible allogeneic stem cell transplantation.

These cells have the potential to form all the different cell types in the body and offer an exciting opportunity to develop new treatment strategies. Embryonic stem cells and iPS cells, however, are not good candidates to be used directly as treatments, as they require careful instruction to become the specific cells needed to regenerate diseased or damaged tissue. If not properly directed, these stem cells may overgrow and cause tumors when injected into the patient.

View clinics that offer the same cell treatment for a wide variety of conditions or diseases with extreme caution. Be wary of claims that stem cells will somehow just know where to go and what to do to treat a specific condition. The more you know about the causes and effects of your disease, the better armed you are to identify your best treatment options.

If you have a certain type of blood cancer, for example, transplantation with blood-forming stem cells makes sense, as the treatment requires those specific cells to do exactly what they are designed to do. Without significant and careful manipulation in the lab, tissue-specific stem cells do not generate cell types found outside of their home tissues.

Your best protection against clinics selling unproven stem cell treatments is an understanding of the science behind your disease, injury or condition.

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In theory, your immune system would not attack your own cells if they were used in a transplant. However, the processes by which the cells were acquired, grown and then reintroduced into the body would carry risks.

Here are just a few known risks of autologous stem cell treatments:. Every medical procedure carries risk; be wary of clinics that gloss over or minimize the risks associated with their treatments.

Mayo Clinic in Florida completes 1,000th blood and marrow transplant

It can be hard to tell the difference between doctors conducting responsible clinical trials and clinics selling unproven treatments. One common differentiator is the way a treatment is marketed. Most specialized doctors receive patient referrals, while clinics selling stem cell treatments tend to market directly to patients, often through persuasive language on the Internet, Facebook and in newspaper advertisements.

Clinics peddling unproven stem cell treatments frequently overstate the benefits of their offerings and use patient testimonials to support their claims. These testimonials can be intentionally or unintentionally misleading. For example, a person may feel better immediately after receiving a treatment, but the perceived or actual improvement may be due to other factors, such as an intense belief that the treatment will work, auxiliary treatments accompanying the main treatment, healthy lifestyle changes adapted in conjunction with the treatment and natural fluctuations in the disease or condition.

Currently, very few stem cell treatments have been proven safe and effective

These factors are complex and difficult to measure objectively outside the boundaries of carefully designed clinical trials. Learn more about why we need to perform clinical trials here. Beware of clinics that use persuasive language, including patient testimonials, on the Internet, Facebook and newspapers, to market their treatments, instead of science-based evidence.

The fact that a procedure is experimental does not automatically mean that it is part of a research study or clinical trial. Responsible clinical trials share several important features:. Responsibly-conducted clinical trials are critical to the development of new treatments.


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Learn more about clinical trials here. Beware of expensive treatments that have not passed successfully through clinical trials. There is a lengthy, multi-step process involved in responsibly translating science into safe and effective medical treatments. During this process, scientists may discover that an approach that seemed promising in the lab, does not work in animals, or that an approach that worked in animals, does not work in humans.

They may discover that a treatment effectively addresses symptoms of a disease or injury in humans, but that it carries unacceptable risks. Scientists carefully review and replicate their work, and invite their peers to do the same.

A Clinical Guide to Stem Cell and Bone Marrow Transplantation A Clinical Guide to Stem Cell and Bone Marrow Transplantation
A Clinical Guide to Stem Cell and Bone Marrow Transplantation A Clinical Guide to Stem Cell and Bone Marrow Transplantation
A Clinical Guide to Stem Cell and Bone Marrow Transplantation A Clinical Guide to Stem Cell and Bone Marrow Transplantation
A Clinical Guide to Stem Cell and Bone Marrow Transplantation A Clinical Guide to Stem Cell and Bone Marrow Transplantation
A Clinical Guide to Stem Cell and Bone Marrow Transplantation A Clinical Guide to Stem Cell and Bone Marrow Transplantation
A Clinical Guide to Stem Cell and Bone Marrow Transplantation A Clinical Guide to Stem Cell and Bone Marrow Transplantation

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